Last update
4/8/2026
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.3
USERS' SCORE
Good
Based on 9 Reviews
8.2
Supplement Facts
Serving Size: 1 Fish Softgel
Amount Per Serving
%DV
Calories
15
Total Fat
1.5 g
2%**
Cholesterol
<5 mg
1%
Vitamin D3 (as Cholecalciferol) (from Lanolin)
25 mcg (1,000 IU)
125%
Fish Oil Concentrate
1.2 g (1,200 mg)
†
Omega-3 Fatty Acids:
Eicosapentaenoic Acid (EPA)
600 mg
†
Docosahexaenoic Acid (DHA)
300 mg
†
Top Medical Research Studies
8
We focused on how Resolvin D1 (RvD1), a pro-resolving lipid, impacts systemic lupus erythematosus (SLE). Our study measured RvD1 levels and T follicular helper (Tfh) cell counts in SLE patients versus healthy individuals.
We found that higher RvD1 levels correlated with lower disease activity and fewer Tfh cells. RvD1 was effective in reducing Tfh cell activity in a mouse model and inhibited Tfh differentiation in lab tests.
Overall, RvD1 appears to play a significant role in managing SLE by suppressing Tfh cells and influencing immune responses.
We found that higher RvD1 levels correlated with lower disease activity and fewer Tfh cells. RvD1 was effective in reducing Tfh cell activity in a mouse model and inhibited Tfh differentiation in lab tests.
Overall, RvD1 appears to play a significant role in managing SLE by suppressing Tfh cells and influencing immune responses.
Read More
7
We analyzed data from 18 randomized controlled trials involving 1018 rheumatoid arthritis (RA) patients to understand the effects of omega-3 supplementation. Our findings revealed that omega-3 significantly increased beneficial fatty acids, EPA, and DHA, while also decreasing harmful triglycerides and tender joint counts.
However, while some inflammation markers showed slight improvements, these changes were not statistically significant. Overall, omega-3 may help manage certain symptoms of RA, but the evidence remains mixed regarding its broader impact on inflammation.
However, while some inflammation markers showed slight improvements, these changes were not statistically significant. Overall, omega-3 may help manage certain symptoms of RA, but the evidence remains mixed regarding its broader impact on inflammation.
Read More
9
We explored the effects of a new, stable form of resolvin D1, called p-MPPF, on autoimmune encephalomyelitis, a condition affecting the nervous system. In our research, both p-MPPF and its unstable counterpart, RvD1, showed significant promise in reducing inflammation and improving symptoms.
This was evidenced by less severe disease progression, better spinal cord health, and changes in immune cell activity. Importantly, we discovered that both substances influenced immune cells in a way that avoids inflammation. Our findings suggest that these types of compounds could lead to improved treatments for autoimmune disorders.
This was evidenced by less severe disease progression, better spinal cord health, and changes in immune cell activity. Importantly, we discovered that both substances influenced immune cells in a way that avoids inflammation. Our findings suggest that these types of compounds could lead to improved treatments for autoimmune disorders.
Read More
Most Useful Reviews
7.5
Hydrated skin
214 people found this helpful
Great Omega! After comparing several brands on this site, I chose Ultra Omega D3 from NOW due to its optimal EPA to DHA ratio, allowing just one capsule a day. Within two weeks, my skin dryness completely vanished, my face and hands became more hydrated, and even my heels stopped peeling. I reordered for my parents, a large pack of 180 capsules should suffice for both. Omega-3 is particularly crucial for older folks as it aids in maintaining vascular health.
Read More
9
Solved issues
186 people found this helpful
Ultra Omega deserves five stars! I ordered it to address specific health concerns, and I can confidently say this dietary supplement worked wonders. I followed the instructions and decided to abandon poor habits easily.
Read More
9
Hydrated skin effects
3 people found this helpful
The best omega in terms of dosage and effect; you only need one a day! I ordered it for myself and my mother, and I noticed my mother’s dry heels disappeared, while my skin became more hydrated. Furthermore, serums and face creams are working better now. I feel good overall and have no complaints.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.3
- All Researches
9
We explored the effects of a new, stable form of resolvin D1, called p-MPPF, on autoimmune encephalomyelitis, a condition affecting the nervous system. In our research, both p-MPPF and its unstable counterpart, RvD1, showed significant promise in reducing inflammation and improving symptoms.
This was evidenced by less severe disease progression, better spinal cord health, and changes in immune cell activity. Importantly, we discovered that both substances influenced immune cells in a way that avoids inflammation. Our findings suggest that these types of compounds could lead to improved treatments for autoimmune disorders.
This was evidenced by less severe disease progression, better spinal cord health, and changes in immune cell activity. Importantly, we discovered that both substances influenced immune cells in a way that avoids inflammation. Our findings suggest that these types of compounds could lead to improved treatments for autoimmune disorders.
Read More
8
Omega-3s may improve SLE outcomes
We explored the effects of omega-3 fatty acids on systemic lupus erythematosus (SLE) using data from 418 participants. Our analysis focused on how different fatty acids relate to disease activity, pain, and sleep quality.
The results highlight that higher levels of long-chain omega-3 fatty acids, particularly DHA, are linked to better outcomes in SLE patients. Although our findings support the idea that omega-3s can be beneficial, more research is needed to confirm these benefits and their long-term effects.
This suggests that improving omega-3 intake through diet could be an effective strategy for managing SLE.
The results highlight that higher levels of long-chain omega-3 fatty acids, particularly DHA, are linked to better outcomes in SLE patients. Although our findings support the idea that omega-3s can be beneficial, more research is needed to confirm these benefits and their long-term effects.
This suggests that improving omega-3 intake through diet could be an effective strategy for managing SLE.
Read More
8
We explored the protective effects of omega-3 fatty acids on insulin-producing cells, particularly focusing on their role in reducing inflammation related to type 1 diabetes. Our findings suggest that omega-3s boost a protein called ARH3, which helps lower the expression of a harmful chemokine, CXCL9.
This mechanism seems to shield β cells from autoimmune attacks, potentially decreasing the risk of developing type 1 diabetes. Overall, while omega-3s show promise as an anti-inflammatory agent, the full impact on autoimmune disorders necessitates further investigation.
This mechanism seems to shield β cells from autoimmune attacks, potentially decreasing the risk of developing type 1 diabetes. Overall, while omega-3s show promise as an anti-inflammatory agent, the full impact on autoimmune disorders necessitates further investigation.
Read More
8
We explored the relationship between omega-3 fatty acids and autoimmune disorders, conducting a comprehensive review and Mendelian randomization analysis.
Our findings indicate that omega-3s provide benefits primarily for rheumatoid arthritis and systemic lupus erythematosus, improving disease activity and reducing inflammation.
However, there was no strong evidence supporting their effectiveness against other autoimmune conditions like psoriasis and multiple sclerosis. This suggests that while omega-3s may benefit certain illnesses, more research is needed for others.
Our findings indicate that omega-3s provide benefits primarily for rheumatoid arthritis and systemic lupus erythematosus, improving disease activity and reducing inflammation.
However, there was no strong evidence supporting their effectiveness against other autoimmune conditions like psoriasis and multiple sclerosis. This suggests that while omega-3s may benefit certain illnesses, more research is needed for others.
Read More
8
We conducted a multicentre, randomised, double-blind, placebo-controlled trial to examine how omega-3 fish oil, specifically from krill oil concentrate (KOC), affects patients with systemic lupus erythematosus (SLE).
Our research showed that KOC effectively corrected omega-3 deficiency and led to a decrease in disease activity for patients with more severe symptoms.
While outcomes were promising, we believe that further studies are necessary to confirm the long-term benefits of omega-3 supplementation for managing lupus.
Our research showed that KOC effectively corrected omega-3 deficiency and led to a decrease in disease activity for patients with more severe symptoms.
While outcomes were promising, we believe that further studies are necessary to confirm the long-term benefits of omega-3 supplementation for managing lupus.
Read More
User Reviews
USERS' SCORE
Good
Based on 9 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Hydrated skin
214 people found this helpful
Great Omega! After comparing several brands on this site, I chose Ultra Omega D3 from NOW due to its optimal EPA to DHA ratio, allowing just one capsule a day. Within two weeks, my skin dryness completely vanished, my face and hands became more hydrated, and even my heels stopped peeling. I reordered for my parents, a large pack of 180 capsules should suffice for both. Omega-3 is particularly crucial for older folks as it aids in maintaining vascular health.
Read More
9
Solved issues
186 people found this helpful
Ultra Omega deserves five stars! I ordered it to address specific health concerns, and I can confidently say this dietary supplement worked wonders. I followed the instructions and decided to abandon poor habits easily.
Read More
9
Hydrated skin effects
3 people found this helpful
The best omega in terms of dosage and effect; you only need one a day! I ordered it for myself and my mother, and I noticed my mother’s dry heels disappeared, while my skin became more hydrated. Furthermore, serums and face creams are working better now. I feel good overall and have no complaints.
Read More
6
Positive physical condition
2 people found this helpful
Omega made a positive impression. It's a great product that I've ordered repeatedly. It has a good concentration, plus vitamin D, with a pleasant lemon aftertaste. I notice a positive effect on my physical condition.
Read More
9
No infections this winter
1 people found this helpful
Great Omega! I've already purchased a second can and plan to order more soon. Omega is fantastic and worth the investment. In my country, such a jar would cost double, so I buy it here. I feel the effect! I started taking it in October, and during that winter season, I didn't catch a single infection, despite previously being ill three to four times a year. Now the whole family drinks it, and I even recommended it to my mother and husband! I'm thrilled and have no regrets.
Read More
Frequently Asked Questions
7.5
Hydrated skin
214 people found this helpful
Great Omega! After comparing several brands on this site, I chose Ultra Omega D3 from NOW due to its optimal EPA to DHA ratio, allowing just one capsule a day. Within two weeks, my skin dryness completely vanished, my face and hands became more hydrated, and even my heels stopped peeling. I reordered for my parents, a large pack of 180 capsules should suffice for both. Omega-3 is particularly crucial for older folks as it aids in maintaining vascular health.
8
Omega-3s may improve SLE outcomes
We explored the effects of omega-3 fatty acids on systemic lupus erythematosus (SLE) using data from 418 participants. Our analysis focused on how different fatty acids relate to disease activity, pain, and sleep quality.
The results highlight that higher levels of long-chain omega-3 fatty acids, particularly DHA, are linked to better outcomes in SLE patients. Although our findings support the idea that omega-3s can be beneficial, more research is needed to confirm these benefits and their long-term effects.
This suggests that improving omega-3 intake through diet could be an effective strategy for managing SLE.
The results highlight that higher levels of long-chain omega-3 fatty acids, particularly DHA, are linked to better outcomes in SLE patients. Although our findings support the idea that omega-3s can be beneficial, more research is needed to confirm these benefits and their long-term effects.
This suggests that improving omega-3 intake through diet could be an effective strategy for managing SLE.
8
We explored the relationship between omega-3 fatty acids and autoimmune disorders, conducting a comprehensive review and Mendelian randomization analysis.
Our findings indicate that omega-3s provide benefits primarily for rheumatoid arthritis and systemic lupus erythematosus, improving disease activity and reducing inflammation.
However, there was no strong evidence supporting their effectiveness against other autoimmune conditions like psoriasis and multiple sclerosis. This suggests that while omega-3s may benefit certain illnesses, more research is needed for others.
Our findings indicate that omega-3s provide benefits primarily for rheumatoid arthritis and systemic lupus erythematosus, improving disease activity and reducing inflammation.
However, there was no strong evidence supporting their effectiveness against other autoimmune conditions like psoriasis and multiple sclerosis. This suggests that while omega-3s may benefit certain illnesses, more research is needed for others.
7
Omega fatty acids show promise, need more research
We explored the potential benefits of omega-3 and omega-6 fatty acids on individuals suffering from Sjögren's syndrome, an autoimmune disorder affecting moisture production. After reviewing several clinical trials, we found that these fatty acids might help alleviate symptoms and inflammation.
However, results are mixed due to variations in study designs and a limited number of trials. Therefore, while promising, we still need further research to fully understand how omega-3 and omega-6 fatty acids can be effectively used in treating this condition.
However, results are mixed due to variations in study designs and a limited number of trials. Therefore, while promising, we still need further research to fully understand how omega-3 and omega-6 fatty acids can be effectively used in treating this condition.
7
We explored how combining a gluten-free diet with omega-3 fatty acids, specifically EPA and DHA, can influence inflammation in women with Hashimoto's thyroiditis.
In our study involving 39 Caucasian female patients, we noted significant reductions in inflammatory markers linked to long-chain fatty acids.
While the dietary changes showed promise in lowering inflammation, there was no significant effect on certain thyroid antibodies. Overall, this diet emphasizes the potential of omega-3s and veggie intake to support those managing this autoimmune disorder.
In our study involving 39 Caucasian female patients, we noted significant reductions in inflammatory markers linked to long-chain fatty acids.
While the dietary changes showed promise in lowering inflammation, there was no significant effect on certain thyroid antibodies. Overall, this diet emphasizes the potential of omega-3s and veggie intake to support those managing this autoimmune disorder.
7
Omega-3 shows limited effectiveness
We examined the effectiveness of omega-3 fatty acids in reducing autoimmune disease (AD) cases within a lengthy randomized trial. While vitamin D showed a notable reduction in AD incidence, omega-3 fatty acids did not demonstrate a statistically significant benefit during the initial phase.
However, after two additional years of monitoring, we found that those taking 1,000 mg/day of omega-3 saw a sustained reduction in AD instances, unlike the diminishing effects of vitamin D.
This suggests omega-3 fatty acids may provide some lasting advantages for AD prevention.
However, after two additional years of monitoring, we found that those taking 1,000 mg/day of omega-3 saw a sustained reduction in AD instances, unlike the diminishing effects of vitamin D.
This suggests omega-3 fatty acids may provide some lasting advantages for AD prevention.
8
We conducted a multicentre, randomised, double-blind, placebo-controlled trial to examine how omega-3 fish oil, specifically from krill oil concentrate (KOC), affects patients with systemic lupus erythematosus (SLE).
Our research showed that KOC effectively corrected omega-3 deficiency and led to a decrease in disease activity for patients with more severe symptoms.
While outcomes were promising, we believe that further studies are necessary to confirm the long-term benefits of omega-3 supplementation for managing lupus.
Our research showed that KOC effectively corrected omega-3 deficiency and led to a decrease in disease activity for patients with more severe symptoms.
While outcomes were promising, we believe that further studies are necessary to confirm the long-term benefits of omega-3 supplementation for managing lupus.
References
- Gilley KN, Fenton JI, Zick SM, Li K, Wang L, et al. Serum fatty acid profiles in systemic lupus erythematosus and patient reported outcomes: The Michigan Lupus Epidemiology & Surveillance (MILES) Program. Front Immunol. 2024;15:1459297. 10.3389/fimmu.2024.1459297
- You Y, Sarkar S, Deiter C, Elliott EC, Nicora CD, et al. Reduction of Chemokine CXCL9 Expression by Omega-3 Fatty Acids via ADP-Ribosylhydrolase ARH3 in MIN6 Insulin-Producing Cells. Proteomics. 2025;25:e202400053. 10.1002/pmic.202400053
- Wang Y, Hu S, Zhang W, Zhang B, Yang Z. Dietary factors and rheumatoid arthritis: new perspectives from a Mendelian randomisation analysis. Br J Nutr. 2025;133:107. 10.1017/S0007114524002721
- Nave CBD, Pereira P, Silva ML. The Effect of Polyunsaturated Fatty Acid (PUFA) Supplementation on Clinical Manifestations and Inflammatory Parameters in Individuals with Sjögren's Syndrome: A Literature Review of Randomized Controlled Clinical Trials. Nutrients. 2024;16. 10.3390/nu16213786
- Szczuko M, Kacprzak J, Przybylska A, Szczuko U, Pobłocki J, et al. The Influence of an Anti-Inflammatory Gluten-Free Diet with EPA and DHA on the Involvement of Maresin and Resolvins in Hashimoto's Disease. Int J Mol Sci. 2024;25. 10.3390/ijms252111692
- Hong K, Hun M, Wu F, Mao J, Wang Y, et al. Association between Omega-3 fatty acids and autoimmune disease: Evidence from the umbrella review and Mendelian randomization analysis. Autoimmun Rev. 2024;23:103651. 10.1016/j.autrev.2024.103651
- Zhang Q, Zhang Y, Zou M, Wu H, Liu C, et al. The chemically stable analogue of resolvin D1 ameliorates experimental autoimmune encephalomyelitis by mediating the resolution of inflammation. Int Immunopharmacol. 2024;140:112740. 10.1016/j.intimp.2024.112740
- Salmon J, Wallace DJ, Rus V, Cox A, Dykas C, et al. Correction of omega-3 fatty acid deficiency and improvement in disease activity in patients with systemic lupus erythematosus treated with krill oil concentrate: a multicentre, randomised, double-blind, placebo-controlled trial. Lupus Sci Med. 2024;11. 10.1136/lupus-2024-001201
- Wang W, Xu Y, Zhou J, Zang Y. Effects of omega-3 supplementation on lipid metabolism, inflammation, and disease activity in rheumatoid arthritis: a meta-analysis of randomized controlled trials. Clin Rheumatol. 2024;43:2479. 10.1007/s10067-024-07040-0
- Cervantes A, Hughes FM, Jin H, Purves JT. Specialized pro-resolution mediators in the bladder: effects of resolvin E1 on diabetic bladder dysfunction in the type 1 diabetic male Akita mouse model. BMC Urol. 2024;24:130. 10.1186/s12894-024-01519-3
- Chen Y, Li Z, Gao Y, Xu B, Zhang W, et al. Fish oil supplementation and risk of incident systemic lupus erythematosus: a large population-based prospective study. Nutr J. 2024;23:63. 10.1186/s12937-024-00965-x
- Kang T, Xi Y, Qian T, Lu S, Du M, et al. Exploring the link between dietary omega-3 and omega-6 fatty acid intake and rheumatoid arthritis risk: NHANES 1999-2020 study. Clin Exp Rheumatol. 2024;42:1720. 10.55563/clinexprheumatol/91tmfb
- Laevski AM, Doucet MR, Doucet MS, LeBlanc AA, Pineau PE, et al. Dietary omega-3 fatty acids modulate the production of platelet-derived microvesicles in an in vivo inflammatory arthritis model. Eur J Nutr. 2024;63:2221. 10.1007/s00394-024-03397-9
- Huang L, Wu J, Cao J, Sheng X, Wang M, et al. Resolvin D1 inhibits T follicular helper cell expansion in systemic lupus erythematosus. Scand J Rheumatol. 2024;53:276. 10.1080/03009742.2024.2344906
- Lin X, Zarghami A, Jelinek GA, Simpson-Yap S, Neate S, et al. Diet and omega-3 and vitamin D supplement use predict five-year fatigue and disability trajectories in people with multiple sclerosis. Mult Scler Relat Disord. 2024;86:105615. 10.1016/j.msard.2024.105615
- Costenbader KH, Cook NR, Lee IM, Hahn J, Walter J, et al. Vitamin D and Marine n-3 Fatty Acids for Autoimmune Disease Prevention: Outcomes Two Years After Completion of a Double-Blind, Placebo-Controlled Trial. Arthritis Rheumatol. 2024;76:973. 10.1002/art.42811
Data last updated:
